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Water‐Soluble Phenanthroline Complexes of Rhodium, Iridium and Ruthenium for the Regeneration of NADH in the Enzymatic Reduction of Ketones (Eur. J. Inorg. Chem. 30/2007)
Author(s) -
Canivet Jérôme,
SüssFink Georg,
Štěpnička Petr
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200790077
Subject(s) - chemistry , rhodium , ruthenium , phenanthroline , catalysis , alcohol dehydrogenase , iridium , enantioselective synthesis , alcohol , formate , ketone , solvent , aqueous solution , formate dehydrogenase , combinatorial chemistry , organic chemistry
The cover picture shows an example of combined organometallic and enzymatic catalysis in aqueous solution. The rhodium complex [(C 5 Me 5 )Rh(phenanthroline)Cl] + continuously regenerates NADH from NAD + by using formate as hydrogen source, and the enzyme alcohol dehydrogenase from Rhodococcus erythropolis enantioselectively reduces the ketone to the corresponding alcohol by means of the NADH formed. This work illustrates the increasing interest in enantioselective catalysis with the environmentally friendly water as solvent. Details are discussed in the article by G. Süss‐Fink et al. on p. 4736 f.