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Chiral Calix[4]arene‐Based Diphosphites as Ligands in the Asymmetric Hydrogenation of Prochiral Olefins
Author(s) -
Marson Angelica,
Freixa Zoraida,
Kamer Paul C. J.,
van Leeuwen Piet W. N. M.
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200700764
Subject(s) - chemistry , enantiomer , calixarene , asymmetric hydrogenation , rhodium , enantioselective synthesis , catalysis , metal , organic chemistry , stereochemistry , combinatorial chemistry , molecule
Chiral calixarene‐based diphosphite ligands 3a – d have been obtained via lower‐rim functionalisation of the p ‐ tert ‐butylcalix[4]arene core. High enantiomeric excesses (up to 94 %) and good activities were obtained in the rhodium‐catalyzed asymmetric hydrogenation of prochiral olefins withTADDOL‐containing diphosphites 3c , d . This is the firstexample of chiral calix[4]arene‐modified ligands that induce high enantioselectivity in metal‐catalysed asymmetric reactions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)