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In Vitro Formation of Nanocrystalline Carbonate Apatite – A Structural and Morphological Analogue of Atherosclerotic Plaques
Author(s) -
Olsson LarsFride,
Sandin Karin,
Odselius Rolf,
Kloo Lars
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200700654
Subject(s) - apatite , chemistry , nanocrystalline material , carbonate , precipitation , in vitro , chemical engineering , nanocrystal , in vivo , calcification , biomineralization , carbonate ion , morphology (biology) , biophysics , nuclear chemistry , mineralogy , crystallography , biochemistry , organic chemistry , geology , engineering , medicine , paleontology , physics , microbiology and biotechnology , pathology , meteorology , biology
The in vitro formation of carbonate apatite in solutions with ion concentrations comparable to those in human serum was studied. The composition and morphology of the resulting apatite precipitate displayed a hierarchical assembly of elongated plate‐shaped nanocrystals of carbonate apatite analogous to previously characterized bioapatites formed in vivo. The main conclusion is that so‐called bioapatites may form in vitro and that precipitation inhibitors most likely are essential for the prevention of spontaneous calcification at normal human serum ion concentrations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)