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Synthesis, Structure, Protolytic Properties, Alkylating and Cytotoxic Activity of Novel Platinum(II) and Palladium(II) Complexes with Pyrazole‐Derived Ligands
Author(s) -
Budzisz Elzbieta,
Malecka Magdalena,
Keppler Bernhard K.,
Arion Vladimir B.,
Andrijewski Grzegorz,
Krajewska Urszula,
Rozalski Marek
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200700139
Subject(s) - chemistry , palladium , protonation , platinum , ligand (biochemistry) , stereochemistry , medicinal chemistry , pyrazole , metal , titration , crystallography , inorganic chemistry , ion , organic chemistry , biochemistry , receptor , catalysis
Novel platinum(II) and palladium(II) complexes [PtCl 2 (HL 1 )] ( 3a ), [NH 2 (CH 3 ) 2 ][PtCl 2 (L 1 )] ( 3b ), [PdCl 2 (HL 1 )] ( 4a ), [NH 2 (CH 3 ) 2 ][PdCl 2 (L 1 )] ( 4b ) and [PdCl(CH 3 CN)(L 1 )] ( 4c ), where HL 1 = 4‐(2‐hydroxybenzoyl)‐2‐(pyridin‐2‐yl)‐1 H ‐pyrazol‐3‐ol, have been synthesised as potential anticancer compounds. Protonation constants of the ligand were determined by pH‐metric titration (log K 1 = 7.74 ± 0.03; log K 2 = 2.85 ± 0.05). The solid‐state structures of complexes 3b and 4c have been determined by X‐ray diffraction, showing square‐planar coordination geometry of Pt II and Pd II ions. In addition, the compounds have been characterised by IR, 1 H NMR and FAB mass spectrometry. The results of preliminary studies on the cytotoxic activity in vitro against HL‐60 and NALM‐6 leukaemia cell lines are also reported and the IC 50 values compared with those of the metal‐free ligand and cisplatin. Cytotoxic evaluation revealed that Pt II and Pd II complexes were active in the micromolar concentration range.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)