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Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives
Author(s) -
Santos M. Amélia,
Gama Sofia,
Pessoa João Costa,
Oliveira M. Conceição,
Tóth Imre,
Farkas Etelka
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200601088
Subject(s) - chemistry , molybdenum , moiety , aqueous solution , iminodiacetic acid , nuclear magnetic resonance spectroscopy , ligand (biochemistry) , chelation , medicinal chemistry , nuclear chemistry , stereochemistry , hydrolysis , inorganic chemistry , organic chemistry , biochemistry , receptor
The molybdenum(VI) binding properties of a series of 3‐hydroxy‐2‐methyl‐4‐pyridinones (3,4‐HP), namely bis(3,4‐HP)chelators, were investigated in solution and as solids; in particular, the complexation of Mo VI with iminobis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, IDAPr(3,4‐HP) 2 , and ethylenediamino‐ N , N′ ‐bis(methylcarboxyl)‐ N , N′ ‐bis{acetyl[1‐(3′‐aminopropyl)‐3‐hydroxy‐2‐methyl‐4‐pyridinone]}, EDTAPr(3,4‐HP) 2 , as well as three model compounds: 1,2‐dimethyl‐3‐hydroxy‐4‐pyridinone (DFP), iminodiacetic acid (IDA), and ethylenediaminodiacetic acid (EDDA). Solution studies show that the complexation occurs at low pH values by the coordination modes of the hydroxypyridinone moiety, and with the formation of bischelated MoO 2 2+ species. As the pH is increased, hydrolytic processes start with the formation of monochelated MoO 3 complexes and is followed by the total recovery of the free ligand, at pH > 8 for most of the systems, but at pH 10 for EDTAPr(3,4‐HP) 2 . The obtained solid molybdenum complexes showed evidence for the presence of mononuclear species in solution, whereas the dinuclear species, (MoO 2 ) 2 EDTAPr(3,4‐HP) 2 , were only detected for the EDTA derivative. Aqueous solution studies were performed by pH–potentiometry, spectrophotometry, 1 H NMR and 17 O NMR spectroscopy, and solid complex species were characterized by elemental analysis, IR spectroscopy, and ESI‐MS.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)