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Alternative Synthesis, Density Functional Calculations and Proton Reactivity Study of a Trinuclear [NiFe] Hydrogenase Model Compound
Author(s) -
Lauderbach Frank,
Prakash Raju,
Götz Andreas W.,
Munoz Marcela,
Heinemann Frank W.,
Nickel Ulrich,
Hess Bernd A.,
Sellmann Dieter
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200601077
Subject(s) - chemistry , density functional theory , reactivity (psychology) , ligand (biochemistry) , nickel , hydrogenase , sulfide , crystallography , valence (chemistry) , valence electron , stereochemistry , medicinal chemistry , computational chemistry , catalysis , electron , organic chemistry , medicine , biochemistry , physics , alternative medicine , receptor , pathology , quantum mechanics
The trinuclear complex [(‘S 2 ’){Ni(PMe 3 )} 2 Fe(CO)(‘S 2 ’) 2 ] ( 1 ) {‘S 2 ’ 2– = 1,2‐benzenedithiolate(2–)} has been reported as a structural as well as functional model for [NiFe] hydrogenases since it contains key structural features of the [NiFe] hydrogenase active site, and is oxidized by protons to give [ 1 ] + and H 2 . Complex 1 formed as an unexpected product from the reaction of [Fe(CO) 2 (‘S 3 ’)] 2 {‘S 3 ’ 2– = bis(2‐mercaptophenyl) sulfide(2–)} and [Ni(PMe 3 ) 2 (‘S 2 ’)]. Both the iron and nickel centers of 1 are chelated by ‘S 2 ’ donors, but not with any ‘S 3 ’ ligand. In order to understand this reaction, the new precursor [Fe(CO) 2 ( si S 3 )] 2 ( 2 ) { si S 3 2– = bis(2‐mercapto‐3‐trimethylsilylphenyl) sulfide(2–)} was synthesized. Compound 2 readily loses its CO ligand to give [Fe(CO)( si S 3 )] 2 ( 3 ), which consists of two 16 valence electron fragments and could be isolated in the solid state. Conversion of 3 to 2 is feasible with gentle bubbling of CO gas for about 2 min. Treatment of 2 with [Ni(PMe 3 ) 2 (‘S 2 ’)] resulted exclusively in the formation of complex 1 , which confirms that all three ‘S 2 ’ ligands in 1 originate from [Ni(PMe 3 ) 2 (‘S 2 ’)]. Therefore, an alternative synthesis of 1 , which does not involve any ‘S 3 ’ ligand, has been developed. Density functional theory (DFT) calculations suggest that the oxidation states of the metal centers are Fe II and Ni II and do not change upon oxidation of 1 to [ 1 ] + . The unpaired electron in [ 1 ] + is located to a large extent on the nickel atoms and the adjacent thiolate donor functions. The charge, however, is distributed over the whole cluster, main parts residing on the ‘S 2 ’ ligands. Preliminary constant potential coulometric measurements indicate that 1 mediates the reduction of protons to dihydrogen at a mild potential (–0.48 V vs. NHE). Based upon these experimental and theoretical results, plausible mechanisms for this reduction are briefly discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)