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Solid‐Phase Synthesis of Chiral Modular Ferrocene‐Based Peptides
Author(s) -
Heinze Katja,
Wild Ute,
Beckmann Manuela
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600857
Subject(s) - chemistry , ferrocene , tripeptide , solid phase synthesis , combinatorial chemistry , peptide synthesis , peptide , phase (matter) , stereochemistry , organic chemistry , biochemistry , electrochemistry , electrode
Ferrocene‐containing tripeptides with one to two ferrocene building blocks were prepared by solid‐phase peptide synthesis (SPPS) using Fmoc‐protected 1′‐aminoferrocene‐1‐carboxylic acid (Fca). The conformations of the tripeptides were analysed by spectroscopic and theoretical methods. The immobilised ferrocene compounds can be reversibly oxidised on‐bead to positively charged peptides and were analysed for anion‐binding affinities by a solid‐phase binding assay. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)