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Towards Polymer Diagnostic Agents ― Copolymers of N ‐(2‐Hydroxypropyl)methacrylamide and Bis(2‐pyridylmethyl)‐4‐vinylbenzylamine: Synthesis, Characterisation and Re(CO) 3 ‐Labelling
Author(s) -
Kunz Peter C.,
Brückmann Nadine E.,
Spingler Bernhard
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600824
Subject(s) - chemistry , methacrylamide , copolymer , rhenium , polymer chemistry , mass spectrometry , ligand (biochemistry) , mass spectrum , polymer , organic chemistry , biochemistry , acrylamide , receptor , chromatography
Diagnosis of early stage angiogenic tumours is fundamental for cancer therapy. In this study we present the synthesis and characterisation of functionalised HPMA‐copolymers with optimal molecular weights that meet the demands of the enhanced permeability and retention (EPR) effect. Rhenium tricarbonyl complexes of the tripodal ligands bis(2‐pyridylmethyl)benzylamine ( 1a ) and bis(2‐pyridylmethyl)‐4‐vinylbenzylamine ( 1b ) were prepared and characterised by 1 H NMR and IR spectroscopy, mass spectrometry and X‐ray diffraction. Ligand 1b was copolymerised with N ‐(2‐hydroxypropyl)methacrylamide (HPMA), and the resulting copolymer was treated with ( n Bu 4 N) 2 [Re(CO) 3 Br 3 ] to yield a Re(CO) 3 ‐labelled copolymer.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)