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The Effect of Catalyst Loading in Copper‐Catalyzed Cyclohexane Functionalization by Carbene Insertion
Author(s) -
Caballero Ana,
DíazRequejo M. Mar,
Trofimenko Swiatoslaw,
Belderraín Tomás R.,
Pérez Pedro J.
Publication year - 2007
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600811
Subject(s) - chemistry , cyclohexane , catalysis , carbene , copper , ligand (biochemistry) , yield (engineering) , surface modification , medicinal chemistry , polymer chemistry , organic chemistry , metallurgy , receptor , biochemistry , materials science
A study of the variables that affect the insertion of the :CHCO 2 Et group (formed from ethyl diazocetate, EDA) into the C–H bonds of cyclohexane in the presence of a Tp x Cu complex as the catalyst (Tp x = trispyrazolylborate ligand) has demonstrated an anomalous effect of the catalyst loading. The use of low concentrations of catalyst produces an increase in the yield of the C–H activation product ethyl cyclohexaneacetate. This effect has also been found in the case of other less elaborated catalysts such as [Bp Br3 Cu] or [(bipy) 2 Cu][I]. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)