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Synthesis and Characterization of [(1 R ,2 R )‐ trans ‐Diaminocyclohexane]platinum(II) Coordinated to Sulfur and Selenium Amino Acids
Author(s) -
Rothenburger Claudia,
Galanski Mathea Sophia,
Arion Vladimir B.,
Görls Helmar,
Weigand Wolfgang,
Keppler Bernhard K.
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600453
Subject(s) - chemistry , selenium , platinum , sulfur , methionine , cysteine , hexafluorophosphate , chelation , nuclear magnetic resonance spectroscopy , stereochemistry , amino acid , inorganic chemistry , organic chemistry , catalysis , biochemistry , ionic liquid , enzyme
Abstract Dichloro[(1 R ,2 R )‐ trans ‐diaminocyclohexane]platinum(II) was activated with Ag 2 CO 3 and then treated with ( S )‐methionine, S ‐methyl‐( S )‐cysteine, ( S )‐selenomethionine and Se ‐methylseleno‐( S )‐cysteine. The N , S ‐ and N , Se ‐chelated platinum(II) species were isolated as hexafluorophosphate salts andcharacterized by multinuclear NMR spectroscopy, ESI‐MS, IR, elemental analyses and, in the case of the ( S )‐methionine and ( S )‐selenomethionine complexes, by X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)