Premium
Hydroxyapatite Nanocrystals Modified with Acidic Amino Acids
Author(s) -
Boanini Elisa,
Fini Milena,
Gazzano Massimo,
Bigi Adriana
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600423
Subject(s) - chemistry , amino acid , crystallite , aspartic acid , aqueous solution , nanocrystal , rietveld refinement , glutamic acid , x ray crystallography , nuclear chemistry , composite number , crystallography , diffraction , crystal structure , stereochemistry , organic chemistry , chemical engineering , biochemistry , materials science , engineering , composite material , physics , optics
HA‐aspartic acid (HA‐ASP) and HA‐glutamic acid (HA‐GLU) composite nanocrystals were synthesized in aqueous medium. The relative amino acid content, determined through HPLC analysis, increases with the amino acid concentration in solution up to a maximum of about 7.8 wt.‐% for HA‐ASP and 4.3 wt.‐% for HA‐GLU composites. The dimensions of the composite nanocrystals decrease on increasing the amino acid content. The line profile analysis of the X‐ray diffraction reflections was performed using: (i) the Scherrer method, (ii) the Warren–Averbach approach, and (iii) the Rietveld refinement. The results indicate that the broadening of the diffraction peaks is partly due to the decrease of crystallite size on increasing amino acid content, and even more to the simultaneous increase of microstrain. The different extent of structural disorder induced by the two amino acids, in agreement with their different incorporation, suggests a greater affinity of aspartic acid for hydroxyapatite structure. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)