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An Entry to Novel Platinum Complexes: Carboxylation of Dihydroxoplatinum(IV) Complexes with Succinic Anhydride and Subsequent Derivatization
Author(s) -
Reithofer Michael,
Galanski Mathea Sophia,
Roller Alexander,
Keppler Bernhard K.
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200600108
Subject(s) - chemistry , succinic anhydride , carboxylation , derivatization , platinum , succinic acid , diamine , organic chemistry , mass spectrometry , carboxylate , nuclear magnetic resonance spectroscopy , medicinal chemistry , catalysis , chromatography
An improved carboxylation method of ( OC ‐6‐33)‐dichloro(ethane‐1,2‐diamine)dihydroxyplatinum(IV) based on succinic anhydride is reported. Reaction of the uncoordinated carboxylic acid with simple amines and alcohols leads to the corresponding amides and esters in the presence of 1,1′‐carbonyldiimidazole. The resulting new complexes are characterized by IR, 1 H, 13 C, 15 N, and 195 Pt NMR spectroscopy, mass spectrometry, and elemental analysis. This reaction provides an entry to a new class of kinetically inert platinum(IV) complexes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)