Premium
Drug Self‐Templated Synthesis of Ibuprofen/Mesoporous Silica for Sustained Release
Author(s) -
Qu Fengyu,
Zhu Guangshan,
Lin Huiming,
Sun Jinyu,
Zhang Daliang,
Li Shougui,
Qiu Shilun
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200501035
Subject(s) - ibuprofen , chemistry , mesoporous silica , mesoporous material , fourier transform infrared spectroscopy , mesoporous organosilica , adsorption , desorption , chemical engineering , aqueous solution , nuclear chemistry , organic chemistry , catalysis , medicine , engineering , pharmacology
The synthesis of Ibuprofen/mesoporous silica has been achieved by a drug self‐templated one‐step co‐condensation process. The drug template of Ibuprofen, a co‐template of 3‐aminopropyltriethoxysilane (APTES), and tetraethoxysiliane (TEOS) were self‐assembled into Ibuprofen/mesoporous silica in a neutral aqueous reaction system. This drug/mesoporous silica was characterized by powder XRD diffraction, FTIR spectroscopy, N 2 adsorption/desorption, TEM, and 29 Si/MAS and 13 C/MAS NMR spectroscopy. The Ibuprofen/mesoporous silica system gives a well‐sustained release profile. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)