Drug Self‐Templated Synthesis of Ibuprofen/Mesoporous Silica for Sustained Release | Zendy

Qu Fengyu | Zendy; Zhu Guangshan | Zendy; Lin Huiming | Zendy; Sun Jinyu | Zendy; Zhang Daliang | Zendy; Li Shougui | Zendy; Qiu Shilun | Zendy

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Drug Self‐Templated Synthesis of Ibuprofen/Mesoporous Silica for Sustained Release

Author(s) -

Qu Fengyu,

Zhu Guangshan,

Lin Huiming,

Sun Jinyu,

Zhang Daliang,

Li Shougui,

Qiu Shilun

Publication year - 2006

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.200501035

Subject(s) - ibuprofen , chemistry , mesoporous silica , mesoporous material , fourier transform infrared spectroscopy , mesoporous organosilica , adsorption , desorption , chemical engineering , aqueous solution , nuclear chemistry , organic chemistry , catalysis , medicine , engineering , pharmacology

The synthesis of Ibuprofen/mesoporous silica has been achieved by a drug self‐templated one‐step co‐condensation process. The drug template of Ibuprofen, a co‐template of 3‐aminopropyltriethoxysilane (APTES), and tetraethoxysiliane (TEOS) were self‐assembled into Ibuprofen/mesoporous silica in a neutral aqueous reaction system. This drug/mesoporous silica was characterized by powder XRD diffraction, FTIR spectroscopy, N 2 adsorption/desorption, TEM, and 29 Si/MAS and 13 C/MAS NMR spectroscopy. The Ibuprofen/mesoporous silica system gives a well‐sustained release profile. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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