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Synthesis, Characterization, and NO Release Study of the cis ‐ and trans ‐[Ru(Bpy) 2 (SO 3 )(NO)] + Complexes
Author(s) -
Silva Francisco O. N.,
Araújo Sérgio X. B.,
Holanda Alda K. M.,
Meyer Emerson,
Sales Francisco A. M.,
Diógenes Izaura C. N.,
Carvalho Idalina M. M.,
Moreira Ícaro S.,
Lopes Luiz G. F.
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200500871
Subject(s) - chemistry , sulfite , hydroxide , imidazole , reactivity (psychology) , medicinal chemistry , ruthenium , reaction rate constant , linkage isomerism , inorganic chemistry , dissociation (chemistry) , stereochemistry , catalysis , kinetics , organic chemistry , metal , medicine , physics , alternative medicine , pathology , quantum mechanics
Abstract Aiming at the development of novel NO donors, the synthesis and reactivity of the trans ‐[Ru(bpy) 2 (SO 3 )(NO)](PF 6 ) and cis ‐[Ru(bpy) 2 (L)(NO)](PF 6 ) n complexes (L = imidazole, isonicotinamide, or sulfite ions) were investigated. The complexes were characterized and the NO release capabilities were evaluated. The rate constant for NO dissociation for the cis ‐[Ru(bpy) 2 (SO 3 )(NO)] + complex is k = 2.0 · 10 –3 s –1 . The cis and trans ‐ [Ru(bpy) 2 (SO 3 )(NO)] + complexes showed promising physical‐chemical properties towards nitric oxide generation, and great stability towards hydroxide attack in the 2.0–9.0 pH range. The reduction potential of the {RuNO} 6/7 process of the cis and trans ‐[Ru(bpy) 2 (SO 3 )NO] + complexes ( E 1/2 =–0.14 and –0.34 V vs. Ag/AgCl) is appropriated for reduction in vivo by biological reducing agents, with consequent NO release. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)