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Novel Water‐Soluble Carbosilane Dendrimers: Synthesis and Biocompatibility
Author(s) -
Ortega Paula,
Bermejo Jesus F.,
Chonco Louis,
de Jesus Ernesto,
de la Mata F. Javier,
Fernández Gerónimo,
Flores Juan Carlos,
Gómez Rafael,
Serramía M. Jesús,
MuñozFernandez M. Angeles
Publication year - 2006
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200500782
Subject(s) - dendrimer , chemistry , biocompatibility , chlorosilane , amine gas treating , hydrolysis , polymer chemistry , organic chemistry , silicon
A synthetic strategy has been developed for the preparation of new peripheral amine‐ or ammonium‐terminated carbosilane dendrimers of type n G‐[Si(OCH 2 CH 2 NMe 2 ) y ] x or n G‐[Si(OCH 2 CH 2 NMe 3 + I – ) y ] x , respectively. It consists of the alcoholysis of well‐known chlorosilane‐terminated dendrimers with N , N ‐dimethylethanolamine and the subsequent quaternization with MeI. All these systems are susceptible to hydrolysis, although the decomposition depends on concentration and dendrimer generation. Evaluation of dendrimer toxicities by phase‐contrast light microscopy and MTT assay were carried out, and evidence of dendrimer/oligonucleotide complex formation was carried out by gel electrophoresis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)