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Kinetic Inertness and Electrochemical Behavior of Copper( II ) Tetraazamacrocyclic Complexes: Possible Implications for in Vivo Stability
Author(s) -
Woodin Katrina S.,
Heroux Katie J.,
Boswell C. Andrew,
Wong Edward H.,
Weisman Gary R.,
Niu Weijun,
Tomellini Sterling A.,
Anderson Carolyn J.,
Zakharov Lev N.,
Rheingold Arnold L.
Publication year - 2005
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200500579
Subject(s) - chemistry , cyclam , protonation , copper , bifunctional , carboxylate , electrochemistry , aqueous solution , inorganic chemistry , conjugate , polymer chemistry , stereochemistry , crystallography , medicinal chemistry , metal , organic chemistry , electrode , catalysis , ion , mathematical analysis , mathematics
The kinetic inertness of copper( II ) complexes of several carboxymethyl‐armed cyclams and cyclens in 5 M HCl have been determined confirming that the complex derived from cross‐bridged cyclam (Cu‐CB‐TE2A) is by far the most resistant to acid decomplexation. FT‐IR studies in D 2 O solution revealed its unique resistance to full carboxylate protonation and its retention of coordination by both pendant arms even in 1 M DCl. The X‐ray structure of its monoprotonated form, [Cu‐CB‐TE2AH] + , also established full coordination by both COO – and COOH pendant arms in the solid state. Cyclic voltammograms of four carboxymethyl pendant‐armed cyclam and cyclen complexes in aqueous solution were obtained with only Cu‐CB‐TE2A displaying a quasi‐reversible Cu II /Cu I reduction wave. These indicators correlate with the superior in vivo behavior of this complex and its bifunctional conjugate. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)