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Synthesis and Electrochemical Characterization of Metallocene–PNA Oligomers
Author(s) -
Maurer Andrea,
Kraatz HeinzBernhard,
MetzlerNolte Nils
Publication year - 2005
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200500316
Subject(s) - chemistry , electrochemistry , ferrocene , monolayer , combinatorial chemistry , conjugate , solid phase synthesis , conjugated system , duplex (building) , cysteine , linker , metallocene , polymer chemistry , dna , stereochemistry , organic chemistry , electrode , peptide , polymerization , polymer , biochemistry , mathematical analysis , mathematics , operating system , computer science , enzyme
The synthesis of ferrocene‐ and cobaltocenium–PNA conjugates with C ‐terminal cysteine residues by solid phase methods is described. Melting points with complementary DNA reveal that both metallocenes stabilize the duplex, although to a different extent. The effect is more pronounced when there is an overhang of the DNA at the PNA amino terminus. The conjugates were studied by electrochemical methods in solution. They were also immobilized on Au microelectrodes in self‐assembled monolayers (SAMs) and further characterized electrochemically on the surface. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)