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Tuning pGa with Chelating Agents Related to ( o ‐Hydroxybenzyl)iminodiacetic Acid
Author(s) -
Jarjayes Olivier,
Mortini Florent,
du Moulinet d’Hardemare Amaury,
Philouze Christian,
Serratrice Guy
Publication year - 2005
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200401036
Subject(s) - chemistry , hexacoordinate , iminodiacetic acid , potentiometric titration , chelation , gallium , ionic strength , aqueous solution , stability constants of complexes , inorganic chemistry , titration , molecule , nuclear chemistry , ionic bonding , medicinal chemistry , stereochemistry , ion , organic chemistry , silicon
Gallium complexes with R‐( o ‐hydroxybenzyl)iminodiacetate ligands ( Lx ) have been synthesized and their thermodynamic constants determined in aqueous solution by potentiometric titration. These quantitative results were also confirmed by 1 H and 19 F NMR spectroscopy. An X‐ray study of Ga L3 (R = NO 2 ) showed that the gallium( III ) ion is hexacoordinate with two H 2 O molecules in cis positions. The ability of the ligands to chelate Ga III was evaluated at physiological pH and ionic strength from the pGa values. Among the different ligands studied, L6 (R = OMe) has a pGa value two orders of magnitude higher than that of the complex between Ga and the blood serum protein transferrin. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)