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A Copper‐Metalated, Hybrid Inorganic–Organic Polymer as an Oxidative Nuclease
Author(s) -
Chandrasekhar Vadapalli,
Athimoolam Arunachalampillai,
Krishnan Venkatasubbaiah,
Azhakar Ramachandran,
Madhavaiah C.,
Verma Sandeep
Publication year - 2005
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200400727
Subject(s) - chemistry , nuclease , singlet oxygen , copper , polymer , oxidative phosphorylation , catalysis , dna , reactive oxygen species , polymer chemistry , combinatorial chemistry , oxygen , organic chemistry , biochemistry
This study describes nucleolytic activity of a copper‐metalated, multisite‐coordinating, hybrid polymer CPPL‐Cu under oxidative conditions. Rapid relaxation of supercoiled plasmid DNA was observed and mechanistic probing by chemical and enzymatic assays revealed involvement of singlet‐oxygen‐derived reactive species. The heterogeneous nature of the catalyst allowed a facile recycling of the artificial nuclease. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)