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Synthesis and Metal‐Complexation Properties of a New Hydroxypyrimidinone‐Functionalized Sepharose
Author(s) -
Esteves M. Alexandra,
Cachudo Anabela,
Chaves Sílvia,
Santos M. Amélia
Publication year - 2005
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200400355
Subject(s) - chemistry , chelation , sepharose , metal ions in aqueous solution , metal , ligand (biochemistry) , derivative (finance) , inorganic chemistry , polymer chemistry , combinatorial chemistry , nuclear chemistry , organic chemistry , enzyme , biochemistry , receptor , financial economics , economics
The 1‐hydroxy‐2‐(1 H )‐pyrimidinone derivative 4‐(3‐aminopropylamino)‐1‐hydroxy‐2‐(1 H )‐pyrimidinone (HOPY‐PrN) was synthesized and its acid‐base and complexation properties towards a set of metal ions (Fe III , Al III , and Th IV ) were studied by potentiometry and spectrophotometry. The ligand was further immobilized in an epoxy‐activated sepharose by chemical coupling through the aminoalkyl pendent group with the aim of improving its sequestering capacity for residual amounts of metals. The new hydroxypyrimidinone‐functionalized sepharose shows a high chelating capacity for metal ions in the pH range 3−8, thus suggesting good perspectives for potential environmental applications. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)