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Gadolinium DTPA‐Monoamide Complexes Incorporated into Mixed Micelles as Possible MRI Contrast Agents
Author(s) -
ParacVogt Tatjana N.,
Kimpe Kristof,
Laurent Sophie,
Piérart Corinne,
Elst Luce Vander,
Muller Robert N.,
Binnemans Koen
Publication year - 2004
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200400187
Subject(s) - gadolinium , micelle , chemistry , amide , alkyl , molecule , organic chemistry , aqueous solution
Four monoamide derivatives of Gd−DTPA with alkyl chains consisting of 12, 14, 16, or 18 carbon atoms were synthesized. The gadolinium( III ) complexes with chain lengths of 14, 16 or 18 carbon atoms were efficiently incorporated into mixed micelles whereas the complex with a chain length of 12 carbon atoms was not incorporated into a micellar structure. The size distribution of the micelles was measured by photon correlation spectroscopy. The mean sizes of the micelles for all the complexes lay within a narrow range, typically between 11 and 20 nm. The NMRD curves of the gadolinium( III ) DTPA‐monoamide complexes incorporated into mixed micelles display higher relaxivity values than the commercially available Gd−DTPA contrast agent. Moreover, micelles with gadolinium DTPA‐monoamide complexes showed higher relaxivities than micelles containing the corresponding gadolinium DTPA‐bis(amide) complexes, most likely because of a more efficient exchange of the coordinated water molecule. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)