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Application of Gel‐Phase 195 Pt NMR Spectroscopy in a Novel Solid‐Phase Synthesis of a Primary Amine Dichloroplatinum (II) Complex
Author(s) -
Robillard Marc S.,
Leith Jason S.,
van der Marel Gijs A.,
van Boom Jacques H.,
Reedijk Jan
Publication year - 2003
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200390199
Subject(s) - chemistry , amine gas treating , nuclear magnetic resonance spectroscopy , platinum , solid phase synthesis , phase (matter) , spectroscopy , nmr spectra database , solid state , primary (astronomy) , combinatorial chemistry , polymer chemistry , organic chemistry , peptide , spectral line , catalysis , biochemistry , physics , quantum mechanics , astronomy
Gel‐phase 195 Pt NMR spectroscopy of dichloroplatinum peptide complexes attached to a solid support is described. The observed 195 Pt chemical shifts of the support‐bound platinum complexes are in good agreement with the solution‐state 195 Pt NMR spectra of the soluble and deprotected analogs. This non‐destructive analytical method for on‐resin‐compound analysis was applied in the optimization of the solid‐phase synthesis of the primary amine dichloroplatinum complex 6 , which represents a new class of platinum complexes now available via solid‐phase synthetic chemistry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)