New Vanadium( V ) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [V v O 2 (salicylaldehyde semicarbazone)] | Zendy

Noblía Pabla | Zendy; Baran Enrique J. | Zendy; Otero Lucía | Zendy; Draper Patricia | Zendy; Cerecetto Hugo | Zendy; González Mercedes | Zendy; Piro Oscar E. | Zendy; Castellano Eduardo E. | Zendy; Inohara Toshifumi | Zendy; Adachi Yusuke | Zendy; Sakurai Hiromu | Zendy; Gambino Dinorah | Zendy

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New Vanadium( V ) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [V v O 2 (salicylaldehyde semicarbazone)]

Author(s) -

Noblía Pabla,

Baran Enrique J.,

Otero Lucía,

Draper Patricia,

Cerecetto Hugo,

González Mercedes,

Piro Oscar E.,

Castellano Eduardo E.,

Inohara Toshifumi,

Adachi Yusuke,

Sakurai Hiromu,

Gambino Dinorah

Publication year - 2004

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.200300421

Subject(s) - chemistry , salicylaldehyde , semicarbazone , vanadium , crystal structure , deprotonation , ligand (biochemistry) , square pyramidal molecular geometry , stereochemistry , crystallography , medicinal chemistry , inorganic chemistry , schiff base , organic chemistry , receptor , ion , biochemistry

The new dioxo(semicarbazone)vanadium( V ) complexes cis ‐VO 2 L, where L = salicylaldehyde semicarbazone (L 1 ), salicylaldehyde 4‐ n ‐butylsemicarbazone (L 2 ), or salicylaldehyde 4‐(2‐naphthyl)semicarbazone (L 3 ), have been synthesized, characterized by 1 H and 13 C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin‐mimetic agents. All dioxovanadium( V ) complexes exhibited essentially no in vitro insulin‐mimetic activity, but the VO 2 L 2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO 2 L 1 has been solved by X‐ray diffraction methods. It crystallizes in the tetragonal space group P 4 2 / n with a = 12.7674(7), c = 11.5308(5) Å, and Z = 8. The vanadium atom is in a distorted square‐pyramidal coordination, with L 1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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