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Synthesis and Characterization of Oxorhenium and Oxotechnetium Complexes with a Novel Tetradentate N 3 O Bifunctional Agent
Author(s) -
Papachristou Maria,
Pirmettis Ioannis,
SiatraPapastaikoudi Theodora,
Pelecanou Maria,
Tsoukalas Charalambos,
Raptopoulou Catherine P.,
Terzis Aris,
Chiotellis Efstratios,
Papadopoulos Minas
Publication year - 2003
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200300298
Subject(s) - chemistry , bifunctional , rhenium , tin , ligand (biochemistry) , square pyramidal molecular geometry , benzoic acid , medicinal chemistry , infrared spectroscopy , chloride , nuclear magnetic resonance spectroscopy , crystallography , stereochemistry , inorganic chemistry , organic chemistry , crystal structure , biochemistry , receptor , catalysis
The novel tetradentate N 3 O bifunctional agent 3‐hydroxy‐4‐[2‐(2′‐pyridinecarboxamido)acetylamino]benzoic acid ( 1 ), reacts with [Bu 4 N][ReOCl 4 ] or [Bu 4 N][ 99g TcOCl 4 ] in EtOH resulting in neutral and stable oxorhenium 2 or oxotechnetium‐99 g 3 complexes. Both complexes were characterized by elemental analysis, IR, 1 H and 13 C NMR spectroscopy. X‐ray analysis of 2 showed that the rhenium atom is pentacoordinate presenting a distorted square‐pyramidal coordination geometry. The analogous oxotechnetium‐99m complex 4 was also prepared quantitatively by the reaction of ligand 1 with Na 99m TcO 4 in isotonic saline using tin chloride as reducing agent. Its identity was established by chromatographic comparison to the oxorhenium 2 and oxotechnetium 3 complexes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)