Premium
Synthesis, Structure and Characterization of New Olivacine Derivatives and Their Platinum( II ) Complexes
Author(s) -
Romaniewska Anna,
JasztoldHoworko Ryszard,
Regiec Andrzej,
Lis Tadeusz,
KudukJaworska Janina
Publication year - 2003
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200300291
Subject(s) - chemistry , intramolecular force , platinum , ligand (biochemistry) , stereochemistry , crystal structure , molecule , chelation , crystallography , proton nmr , organic chemistry , receptor , catalysis , biochemistry
Three unknown olivacine derivatives ( L ‐OCH 3 , L ‐OH, L ‐OAc) were synthesized according to a procedure that involves only a few steps, and used as ligands in the synthesis of neutral chelate platinum( II ) complexes. The ligands, as well as their platinum complexes were spectroscopically characterized with IR, 1 H/ 13 C NMR and UV/Vis spectroscopic techniques. The solid state structures of two ligands ( L ‐OCH 3 , L ‐OAc) and one complex {[( L ‐OCH 3 )PtCl 2 ]} were determined by X‐ray diffraction. Molecular structure analysis of the ligands and the complex indicated that complexation resulted in a change in the conformation of the bipyridine fragment of the compounds studied and caused other interesting effects. Two crystallographically independent molecules of the complex were revealed in the measured crystal, with short intramolecular H ··· H distances. The structural and energetic aspects of the conformational behavior of the ligand L ‐OCH 3 and the complex [( L ‐OCH 3 )PtCl 2 ] have been analyzed using semiempirical PM3 methods. In vitro antiproliferative activity was preliminarily estimated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)