A Novel Water‐Soluble Tripodal Imidazolyl Ligand as a Model for the Tris(histidine) Motif of Zinc Enzymes: Nickel, Cobalt and Zinc Complexes and a Comparison with Metal Binding in Carbonic Anhydrase | Zendy

Kunz Peter C. | Zendy; Reiß Guido J. | Zendy; Frank Walter | Zendy; Kläui Wolfgang | Zendy

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A Novel Water‐Soluble Tripodal Imidazolyl Ligand as a Model for the Tris(histidine) Motif of Zinc Enzymes: Nickel, Cobalt and Zinc Complexes and a Comparison with Metal Binding in Carbonic Anhydrase

Author(s) -

Kunz Peter C.,

Reiß Guido J.,

Frank Walter,

Kläui Wolfgang

Publication year - 2003

Publication title -

european journal of inorganic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.667

H-Index - 136

eISSN - 1099-0682

pISSN - 1434-1948

DOI - 10.1002/ejic.200300228

Subject(s) - chemistry , carbonic anhydrase , zinc , tris , cobalt , nickel , ligand (biochemistry) , histidine , carbonic anhydrase ii , metal , methanol , medicinal chemistry , stereochemistry , aqueous solution , tripodal ligand , crystal structure , inorganic chemistry , enzyme , polymer chemistry , organic chemistry , receptor , biochemistry

Tris[2‐isopropylimidazol‐4(5)‐yl]phosphane (4‐TIP i Pr ), a novel model ligand for the tris(histidine) motif of many zinc enzymes, has been prepared. 4‐TIP i Pr is hydrolytically stable and soluble in protic solvents. It readily forms chloro‐ and nitratocobalt, ‐nickel and ‐zinc complexes in aqueous methanol. The crystal structures of the solvates [(4‐TIP i Pr )Co(MeOH)(NO 3 )]NO 3 ·2Et 2 O ( 3· 2Et 2 O), [(4‐TIP i Pr )Ni(MeOH)(NO 3 )]NO 3 ·Et 2 O·MeOH ( 4· Et 2 O·MeOH), [(4‐TIP i Pr )CoCl]Cl·MeOH·2.5H 2 O ( 5· MeOH·2.5H 2 O), and [(4‐TIP i Pr )ZnCl]Cl·MeOH·2.5H 2 O ( 6· MeOH·2.5H 2 O) have been determined. The complex 3 shows striking structural similarities to the hydrogencarbonate complex of cobalt‐substituted human carbonic anhydrase II (HCA II). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

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