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Synthesis, Characterization, and DNA Binding Studies of a Chromium( III ) Complex Containing a Tridentate Ligand
Author(s) -
Vaidyanathan Vaidyanathan Ganesan,
Nair Balachandran Unni
Publication year - 2003
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200300170
Subject(s) - chemistry , titration , fluorescence , chromium , dna , ligand (biochemistry) , pyridine , absorption (acoustics) , absorption spectroscopy , crystallography , inorganic chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , receptor , physics , quantum mechanics , acoustics
[Cr(bzimpy) 2 ]Cl, where bzimpy is 2,6‐bis(benzimidazol‐2‐yl)pyridine, has been synthesized and characterized by ESI‐MS, UV/Visible, and fluorescence spectra. Absorption titration and thermal denaturation experiments indicate that the complex binds to DNA with moderate strength, while viscosity measurements show that it may undergo surface binding. The fluorescence intensity of the complex increases with increasing DNA concentration, in contrast to [Cr(phen) 3 ] 3+ and [Cr(bpy) 3 ] 3+ . The complex cleaves pBR322 DNA in the presence of H 2 O 2 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)