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Synthesis, Characterisation and Antiamoebic Studies of Dioxovanadium( V ) Complexes Containing ONS Donor Ligands Derived from S ‐Benzyldithiocarbazate
Author(s) -
Maurya Mannar R.,
Khurana Shilpa,
Azam Amir,
Zhang Wenjian,
Rehder Dieter
Publication year - 2003
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.200200642
Subject(s) - chemistry , salicylaldehyde , stereochemistry , tautomer , entamoeba histolytica , hydrogen bond , supramolecular chemistry , molecule , intermolecular force , counterion , medicinal chemistry , schiff base , organic chemistry , ion , microbiology and biotechnology , biology
Three new dioxovanadium( V ) compounds, [K(H 2 O)][VO 2 (sal‐sbdt)] ( 1 ), [K(H 2 O) 2 ][VO 2 (Clsal‐sbdt)] ( 2 ), and [K(H 2 O) 2 ][VO 2 (Brsal‐sbdt)] ( 3 ) (where H 2 sal‐sbdt are the Schiff bases formed between salicylaldehyde and dithiocarbazates) have been synthesised, and the structures of 1 and 2 revealed by X‐ray diffraction analyses. The ligands coordinate in the tridentate ONS fashion out of the enethiolate tautomeric form. The potassium counterions, coordinated to water molecules, the phenolate‐O, the oxo groups on vanadium and, in the case of 1 , to the thiolate, provide interlinkages between the anions and thus a complex supramolecular network, further reinforced by intermolecular hydrogen bonds between oxo groups and water molecules. In vitro tests of the antiamoebic activity against the protozoan parasite Entamoeba histolytica showed comparable ( 1 and 2 ) or substantially better ( 3 ) amoebocidal action than metronidazole, a commonly used drug against amoebobiasis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)