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Enrichment of CCR6 + CD8 + T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19
Author(s) -
Saris Anno,
Reijnders Tom D.Y.,
Reijm Martine,
Hollander Jolien C.,
de Buck Kim,
Schuurman Alex R.,
Duitman JanWillem,
Heunks Leo,
Aman Jurjan,
Bogaard Harm Jan,
Nossent Esther J.,
van der Poll Tom,
Bontkes Hetty J.
Publication year - 2021
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.202049046
Subject(s) - c c chemokine receptor type 6 , ccl20 , cd8 , biology , covid-19 , cxcr3 , immunity , immunology , microbiology and biotechnology , chemokine , immune system , pathology , medicine , chemokine receptor , disease , infectious disease (medical specialty)
Despite high levels of CXCR3 ligands in mechanically ventilated COVID‐19 patients, BALF CD8 T cells were not enriched in CXCR3 + cells but rather CCR6 + , likely due to high CCL20 levels in BALF, and had very high PD‐1 expression. In mechanically ventilated, but not ward, patients Th‐1 immunity is impaired.