Premium
Slow cytomegalovirus‐specific CD4 + and CD8 + T‐cell differentiation: 10‐year follow‐up of primary infection in a small number of immunocompetent hosts
Author(s) -
Fornara Chiara,
Furione Milena,
Zavaglio Federica,
Arossa Alessia,
Spinillo Arsenio,
Gerna Giuseppe,
Lilleri Daniele
Publication year - 2021
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.202048772
Subject(s) - biology , cd8 , cytomegalovirus , virology , microbiology and biotechnology , genetics , virus , herpesviridae , immune system , viral disease
Differentiation of human cytomegalovirus specific T cells is a slow process requiring years. In the acute phase, EM predominate; subsequently, no contraction occurs (memory inflation) and T EMRA increase, especially among CD8 + T cells, while few LTM T cells appear. After some years, LTM stabilizes and predominate among CD4 + .