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Model answers: Rational application of murine models in arthritis research
Author(s) -
Benson Robert A.,
McInnes Iain B.,
Garside Paul,
Brewer James M.
Publication year - 2018
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.201746938
Subject(s) - rheumatoid arthritis , disease , relevance (law) , arthritis , human disease , animal model , intensive care medicine , process (computing) , biology , pathogenesis , computational biology , bioinformatics , risk analysis (engineering) , data science , immunology , computer science , medicine , pathology , political science , law , endocrinology , operating system
Abstract Advances in targeted immune therapeutics have profoundly improved clinical outcomes for patients with inflammatory arthropathies particularly rheumatoid arthritis. The landscape of disease that is observed and the treatment outcomes desired for the future have also progressed. As such there is an increasing move away from traditional models of end‐stage, chronic disease with recognition of the need to consider the earliest phases of pathogenesis as a target for treatment leading to resolution and/or cure. In order to continue the discovery process and enhance our understanding of disease and treatment, we therefore need to continuously revisit the animal models we employ and assess their relevance and utility in the light of contemporary therapeutic goals. In this review, we highlight the areas where we consider new developments in animal models and their application are most required. Thus, we have contextualised the relevant mouse models and their use within the current concepts of human inflammatory arthritis pathogenesis and highlight areas of need.