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Monocyte‐derived dendritic cells enhance protection against secondary influenza challenge by controlling the switch in CD8 + T‐cell immunodominance
Author(s) -
Cruz Jazmina L. G.,
PérezGirón José V.,
Lüdtke Anja,
GómezMedina Sergio,
Ruibal Paula,
Idoyaga Juliana,
MuñozFontela César
Publication year - 2017
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.201646523
Subject(s) - biology , immunodominance , cd8 , virology , cytotoxic t cell , influenza a virus , immunity , dendritic cell , virus , t cell , immunology , immune system , genetics , in vitro
Influenza virus infection triggers an increase in the number of monocyte‐derived dendritic cells (moDCs) in the respiratory tract, but the role of these cells during antiviral immunity is still unclear. Here we show that during influenza infection, moDCs dominate the late activation of CD8 + T cells and trigger the switch in immunodominance of the CD8 + T‐cell response from acidic polymerase specificity to nucleoprotein specificity. Abrogation of monocyte recruitment or depletion of moDCs strongly compromised host resistance to secondary influenza challenge. These findings underscore a novel function of moDCs in the antiviral response to influenza virus, and have important implications for vaccine design.