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Development of CD27 + marginal zone B cells requires GALT
Author(s) -
Yeramilli Venkata A.,
Knight Katherine L.
Publication year - 2013
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.201243205
Subject(s) - marginal zone , biology , spleen , cd23 , b cell , immunology , lymphatic system , microbiology and biotechnology , antibody , immunoglobulin e
In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross‐reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27 + CD23 − . In rabbits in which organized gut‐associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23 + follicular (FO) B cells and almost no CD27 + MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells. These findings lead us to suggest that commensal microbiota contribute to the development of MZ B cells.