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Cover Picture: Eur. J. Immunol. 11/10
Author(s) -
Hamel Keith M.,
Cao Yanxia,
Wang Yumei,
Rodeghero Rachel,
Kobezda Tamas,
Chen Lieping,
Finnegan Alison
Publication year - 2010
Publication title -
european journal of immunology
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.201090062
Subject(s) - biology , h&e stain , immunology , immunization , microbiology and biotechnology , antibody , immunohistochemistry
Abstract The cover image of this issue consists of an hematoxylin and eosin staining of a sagittal section of hind paw harvested from a wild‐type BALB/c mouse 6 weeks after proteoglycan (PG)‐dimethyldioctadecyl‐ammonium bromide (DDA) immunization, and is taken from Hamel et al . ( pp . 3117–3127). In this article, the authors examine the role of the programmed death (PD)‐1 ligand, B7‐H1, in the development of PG‐induced arthritis (PGIA). The authors show that B7‐H1 −/− mice exhibit exacerbated PGIA and increased Th1 CD4 + T‐cell responses, while the PG‐specific antibody response in these mice is diminished.