Premium
ICOS‐dependent stimulation of NKT cells by marginal zone B cells
Author(s) -
Zietara Natalia,
Łyszkiewicz Marcin,
Krueger Andreas,
Weiss Siegfried
Publication year - 2011
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.201041092
Subject(s) - natural killer t cell , cd1d , biology , microbiology and biotechnology , marginal zone , stimulation , immune system , glucocorticoid receptor , glucocorticoid , receptor , immunology , t cell , b cell , endocrinology , antibody , biochemistry
Abstract Marginal zone (MZ) B cells express high levels of CD1d molecules. In accordance, MZ B cells, like splenic conventional DCs (cDCs), efficiently trigger NKT‐cell proliferation. Importantly, MZ B cells exclusively induced production of IL‐4 and IL‐13 by such cells whereas cDCs induced robust production of mainly IFN‐γ. NKT‐cell proliferation, IL‐4 and IL‐13 production induced by MZ B cells were dependent on ICOS/ICOS ligand interaction while IFN‐γ and IL‐17 induction by cDCs required glucocorticoid‐induced TNF receptor/glucocorticoid‐induced TNF receptor ligand interplay. Our data illustrate that both MZ B cells and cDCs act as efficient APCs for NKT cells and might differentially influence the quality of the subsequent immune response.