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Cover Picture: Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin‐specific antibodies – Eur. J. Immunol. 7/2008
Author(s) -
von Büdingen HansChristian,
Harrer Melanie D.,
Kuenzle Sandra,
Meier Mirjam,
Goebels Norbert
Publication year - 2008
Publication title -
european journal of immunology
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.200890029
Subject(s) - cerebrospinal fluid , multiple sclerosis , monoclonal antibody , myelin , antibody , biology , pathology , axon , antigen , white matter , immunohistochemistry , microbiology and biotechnology , central nervous system , immunology , medicine , neuroscience , magnetic resonance imaging , radiology
Abstract The cover shows a confocal micrograph of myelinated nervous tissue at the rim of a demyelinating lesion in the brain white matter of a patient with multiple sclerosis (MS). Myelin surrounding the axon is stained by a monoclonal antibody obtained by recombinant expression of immunoglobulin genes from clonally expanded plasma cells as present in the cerebrospinal fluid of MS patients. The image was taken from the article by von Büdingen et al. ( pp. 2014–2023) in which the authors demonstrate that myelin specific antibodies result from antigen driven immune responses found in the cerebrospinal fluid of MS patients.