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Cover Picture: Nanoparticles target distinct dendritic cell populations according to their size – Eur. J. Immunol. 5/2008
Author(s) -
Manolova Vania,
Flace Anna,
Bauer Monika,
Schwarz Katrin,
Saudan Philippe,
Bachmann Martin F.
Publication year - 2008
Publication title -
european journal of immunology
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.200890018
Subject(s) - lymph , lymphatic system , lymph node , cover (algebra) , biology , particle (ecology) , anatomy , biophysics , pathology , immunology , medicine , mechanical engineering , engineering , ecology
Abstract The cover shows a colour series of mouse footpads injected with small fluorescent nanoparticles. The image depicts the afferent lymphatic vessels connecting the injection site with the draining popliteal lymph node and the more distal sciatic lymph node. Lymphatic vessels (in green in the left row) run together with the veins (darker curves) and carry free draining antigen to the lymph nodes. This image was provided by the authors of Manolova ( pp.1404–1413) , in which it is demonstrated that particle size critically influences the mode of antigen transport to the draining lymph nodes; DC are strictly required for transport of large (500–2000 nm) particles, whereas smaller particles (20–200 nm), such as virus‐like particles (30 nm), drain freely.