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Cover Picture: Accelerating the secondary immune response by inactivating CD4 + CD25 + T regulatory cells prior to BCG vaccination does not enhance protection against tuberculosis – Eur. J. Immunol. 3/2008
Author(s) -
Quinn Kylie M.,
Rich Fenella J.,
Goldsack Lisa M.,
de Lisle Geoffrey W.,
Buddle Bryce M.,
Delahunt Brett,
Kirman Joanna R.
Publication year - 2008
Publication title -
european journal of immunology
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.200890007
Subject(s) - vaccination , immunology , immune system , mycobacterium bovis , il 2 receptor , biology , immunity , antigen , tuberculosis , mycobacterium tuberculosis , virology , t cell , medicine , pathology
Abstract The cover shows a lung section taken from mice treated i.p. with PC61 (a mAb to CD25), vaccinated with bacillus Calmette‐Guérin (BCG) 3 days later and then challenged with Mycobacterium bovis via aerosol a further 42 days later. The section is stained with hematoxylin and eosin, and shows that pulmonary inflammation, although present, is limited. The image is taken from Quinn et al. ( pp. 695–705) in which the authors demonstrate that inactivation of CD4 + CD25 + natural Treg does not influence the development of protective immunity following BCG vaccination, even though the immune response to mycobacterial antigens early after vaccination is increased.