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From phagocyte diversity and activation to probiotics: Back to Metchnikoff
Author(s) -
Mantovani Alberto
Publication year - 2008
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.200838918
Subject(s) - biology , phagocyte , mononuclear phagocyte system , immunology , macrophage , innate immune system , phagocytosis , immune system , genetics , in vitro
Abstract In this issue of the European Journal of Immunology, Siamon Gordon gives a detailed account of Metchnikoff's life and his achievements ( Eur. J. Immunol. 2008. 38: 3257–3264). Looking back at the roots of innate immunity stimulates reflections on open issues in the field. Here, I give a personal view of some of these issues, including myeloid‐derived suppressor cells, macrophage polarization and adaptive responses of mononuclear phagocytes.