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Resident enteric microbiota and CD8 + T cells shape the abundance of marginal zone B cells
Author(s) -
Wei Bo,
Su Thomas T.,
Dalwadi Harnisha,
Stephan Robert P.,
Fujiwara Daisuke,
Huang Tiffany T.,
Brewer Sarah,
Chen Lindy,
Arditi Moshe,
Borneman James,
Rawlings David J.,
Braun Jonathan
Publication year - 2008
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.200838432
Subject(s) - biology , cd8 , microbiology and biotechnology , cytotoxic t cell , innate immune system , priming (agriculture) , immunology , immune system , genetics , in vitro , germination , botany
Abstract Since enteric microbial composition is a distinctive and stable individual trait, microbial heterogeneity may confer lifelong, non‐genetic differences between individuals. Here we report that C57BL/6 mice bearing restricted flora microbiota, a distinct but diverse resident enteric microbial community, are numerically and functionally deficient in marginal zone (MZ) B cells. Surprisingly, MZ B‐cell levels are minimally affected by germ‐free conditions or null mutations of various TLR signaling molecules. In contrast, MZ B‐cell depletion is exquisitely dependent on cytolytic CD8 + T cells, and includes targeting of a cross‐reactive microbial/endogenous MHC class 1B antigen. Thus, members of certain enteric microbial communities link with CD8 + T cells as a previously unappreciated mechanism that shapes innate immunity dependent on innate‐like B cells.