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Regulation of cathepsin E expression during human B cell differentiation in vitro
Author(s) -
Sealy Louise,
Mota Fernando,
Rayment Neil,
Tatnell Peter,
Kay John,
Chain Benjamin
Publication year - 1996
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830260826
Subject(s) - biology , cathepsin l1 , cathepsin e , cathepsin h , cathepsin l , cathepsin o , cathepsin , cathepsin d , cathepsin b , microbiology and biotechnology , cathepsin a , in vitro , function (biology) , major histocompatibility complex , cathepsin s , antigen , immunology , enzyme , biochemistry
Abstract Cathepsin E is an aspartic proteinase which has been implicated in antigen processing in the class II major histocompatibility complex pathway. In this study we show that cathepsin E, measured at both the protein and message level, is up‐regulated late in human B cell activation. The implications of this observation in terms of cathepsin E function are discussed.