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Human natural killer cell inhibitory receptors bind to HLA class I molecules
Author(s) -
Döhring Christian,
Colonna Marco
Publication year - 1996
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830260215
Subject(s) - biology , receptor , human leukocyte antigen , major histocompatibility complex , natural killer cell , microbiology and biotechnology , serine , inhibitory postsynaptic potential , immunology , genetics , gene , cytotoxic t cell , antigen , in vitro , phosphorylation , neuroscience
Abstract To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK‐associated transcript‐2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA‐C alleles with serine 77 and asparagine 80 in cell adhesion assays.