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Disease in the scurfy ( sf ) mouse is associated with overexpression of cytokine genes
Author(s) -
Kanangat Sivadasan,
Blair Patrick,
Reddy Ramani,
Deheshia Massoud,
Godfrey Virginia,
Rouse Barry T.,
Wilkinson Erby
Publication year - 1996
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830260125
Subject(s) - biology , hypergammaglobulinemia , immunology , cytokine , lymphoproliferative disorders , lymphoma , antibody
Abstract The murine X‐linked lymphoproliferative disease scurfy is similar to the Wiskott‐Aldrich syndrome in humans. Disease in scurfy ( sf ) mice is mediated by CD4 + T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesions of sf mice by Northern blotting, quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) and by hybridization in situ. Overall, the phenotypic characteristics of scurfy disease correlated well with increased interleukin (IL)‐4 (lymphadenopathy), IL‐6 (B cell proliferation, hypergammaglobulinemia), IL‐7 (dermal inflammatory cell infiltration), and high levels of tumor necrosis factor‐α (wasting).