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The presence of the HLA class. II allele DPB1*0501 in ethnic Thais correlates with an enhanced vaccine‐induced antibody response to a malaria sporozoite antigen
Author(s) -
Stephens Henry A. F.,
Brown Arthur E.,
Chandanayingyong Dasnayanee,
Webster H. Kyle,
Sirikong Monchan,
Longta Panpimon,
Vangseratthana Rapeepun,
Gordon Daniel M.,
Lekmak Somboon,
Rungruang Ekaraj
Publication year - 1995
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830251123
Subject(s) - biology , circumsporozoite protein , allele , immunology , thais , human leukocyte antigen , plasmodium falciparum , antibody , antigen , virology , immune system , immunogenetics , malaria , genetics , gene , demography , sociology
Abstract In this study, we examined the correlation between the frequency of allelic variants of the class II human leukocyte antigen (HLA) DR, DQ and DP gene loci and the quantitative humoral immune response observed in 71 Thai volunteers, subsequent to vaccination with a conjugated subunit vaccine. This vaccine was designed to induce antibodies directed against the immunodominant repeat region of the Plasmodium falciparum circumsporozoite (CS) protein. The presence of the DPB1*0501, a relatively common allele in Asian populations, was found to be associated with high vaccine‐induced CS repeat‐specific antibody responses in the volunteers. Given the increasing focus on the use of subunit vaccines in the control of infectious diseases, consideration of the influence of class II allele frequencies in ethnically diverse recipient populations may be important.