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Restriction of self‐antigen presentation to cytolytic T lymphocytes by mouse peptide pumps
Author(s) -
Gournier Héène,
Pascolo Steve,
Siegrist ClaireAnne,
Jehan Josette,
Pérarnau Béatrice,
Garcia Zacarias,
Rose Thierry,
Neefjes Jacques,
Lemonnier François A.
Publication year - 1995
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830250733
Subject(s) - biology , ctl* , antigen presentation , major histocompatibility complex , mhc restriction , mhc class i , antigen , antigen processing , peptide , peptide sequence , microbiology and biotechnology , immune system , t cell , immunology , cd8 , biochemistry , gene
Abstract Transport of an immunogenic self‐peptide from the second domain of the mouse major histocompatibility complex (MHC) H‐2K d class I molecule is blocked at the TAP1‐TAP2 peptide pump level due to its amino acid sequence and is not presented to cytolytic T lymphocytes (CTL). We demonstrate that first, TAP1‐TAP2 pumps can restrict antigen presentation by selecting against internal peptide motifs which are not involved in peptide binding to MHC class I molecules. Second, some molecules targeted to the endoplasmic reticulum are processed for MHC class I presentation in the cytosol. Third, some abundantly expressed immunogenic self‐peptides are cytosolically sequestered. The advantage for the host, in terms of the peripheral T cell repertoire is that the spared CTL can be used to recognize foreign antigens. It is, however, anticipated that this advantage will be exploited by pathogens to evade immune surveillance by similar strategies.