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Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction
Author(s) -
Shu Uno,
Kiniwa Mamoru,
Wu Chang You,
Maliszewski Charles,
Vezzio Nadia,
Hakimi John,
Gately Maurice,
Delespesse Guy
Publication year - 1995
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830250442
Subject(s) - cd40 , biology , microbiology and biotechnology , interleukin 4 , monocyte , immunology , cytokine , biochemistry , in vitro , cytotoxic t cell
Abstract Previous studies on the production of interleukin‐12 (IL‐12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL‐12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL‐12 by monocytes via a mechanism involving the interaction of T cell‐associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.