Premium
Expression of the mouse interleukin‐2 receptor γ chain in various cell populations of the thymus and spleen
Author(s) -
Kondo Motonari,
Ohashi Yoichi,
Tada Kohtaro,
Nakamura Masataka,
Sugamura Kazuo
Publication year - 1994
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830240914
Subject(s) - biology , spleen , haematopoiesis , microbiology and biotechnology , receptor , t cell , flow cytometry , interleukin 15 , immunology , interleukin , cytokine , stem cell , immune system , genetics
Abstract Expression of the γ chain, which is shared among functional receptor complexes for interleukin (IL)‐2, IL‐4 and IL‐7, was examined with hematopoietic cells in mouse thymus and spleen by flow cytometry. The γ chain was expressed in cell populations from the spleen. Stimulation with concanavalin A and lipopolysaccharide caused fluctuation in expression of the γ chain in T and B cells, respectively. T lineage cells developing in the adult thymus expressed the γ chain. Fetal thymus at day 15 contained mostly immature thymocytes, which also expressed the γ chain. These results demonstrate that the γ chains is widely expressed in T lineage cells, probably indicating that the γ chain plays a role not only in the proliferation of mature hematopoietic cells but also in the development of immature cells through signal transduction as a common receptor subunit for multiple cytokines.