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Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice
Author(s) -
Katz Jonathan,
Benoist Christophe,
Mathis Diane
Publication year - 1993
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830231244
Subject(s) - insulitis , islet , biology , major histocompatibility complex , cd8 , nod , nod mice , immunology , effector , diabetes mellitus , endocrinology , immune system
Abstract An early step in the development of autoimmune diabetes is lymphocyte infiltration into the islets of Langerhans of the pancreas, or insulitis. The infiltrate contains both CD4 + and CD8 + T cells and both are required for progression to diabetes in non‐obese diabetic (NOD) mice. It has been thought that the CD4 + lymphocytes are the initiators of the disease, the islet invaders, while CD8 + cells are the effectors, the islet destroyers. We question this interpretation because NOD mice lacking MHC class I molecules, hence CD8 + T cells, do not display even insulitis when expected.