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Antigen processing mutant T2 cells present viral antigen restricted through H‐2K
Author(s) -
Zhou Xianzheng,
Glas Rickard,
Liu Tianmin,
Ljunggren HansGustaf,
Jondal Mikael
Publication year - 1993
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830230811
Subject(s) - antigen processing , biology , antigen presentation , cytotoxic t cell , antigen , sendai virus , mhc restriction , ctl* , mhc class i , cross presentation , major histocompatibility complex , transporter associated with antigen processing , antigen presenting cell , cd8 , virology , microbiology and biotechnology , immunology , virus , genetics , in vitro
Abstract Cytotoxic T lymphocytes (CTL) recognize foreign antigens as short peptides presented by class I molecules of the major histocompatibility complex (MHC). T2 cells are profoundly defective in the presentation of endogenously synthesized antigens to CTL due to a deletion of MHC class II‐encoded genes for transporters associated with antigen presentation (TAP1/TAP2). Surprisingly, we here demonstrate that T2 cells, after infection with Sendai virus, are readily killed by H‐2K b restricted CD8 + T cells. In contrast to classical class I‐mediated antigen presentation, the presentation of Sendai virus antigen inT2K b cells is brefeldin A (BFA) insensitive. The present findings may suggest the presence of an alternative pathway for MHC class I‐mediated antigen presentation in T2 cells.