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Selective disbalances of peripheral blood T lymphocyte subsets in human CD3γ deficiency
Author(s) -
Timón Marcos,
ArnaizVillena Antonio,
RodríguezGallego Carlos,
PérezAciego Paloma,
Pacheco Alberto,
Regueiro Jose R.
Publication year - 1993
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830230706
Subject(s) - cd3 , t cell receptor , biology , cd8 , immunology , t lymphocyte , lymphocyte , t cell , antigen , microbiology and biotechnology , immune system
Abstract The selection of T lymphocytes in the thymus and their activation upon the encounter with foreign antigens in the periphery require the aggregation and signals of the Tcell receptor (TcR)/CD3 complex and several surface molecules termed coreceptors (notably CD4 or CD8 and CD45). The spatial arrangement and interactions of the different molecules in the resulting multimolecular recognition structure are mostly unknown. Here we report, from studies on a healthy human CD3γ deficiency, that the lack of the CD3γ component of the TcR/CD3 complex is associated with a long‐term severe defect of peripheral blood CD4 + CD45RA + and CD8+ lymphocytes, whereas CD4 + CD45RO + , B and natural killer lymphocytes are unaffected. These results suggest that the CD3y site of the TcR/CD3 complex is required for the peripheral representation of certain Tcell types.